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  • The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) greater than 27, provided they also have problems with weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (hypertension).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle which includes a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight-loss for people who are obese or are overweight and possess at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercising. Results from a clinical study that enrolled patients without diabetes showed that patients had an average weight loss of four.1% as opposed to participants who were given placebos) during a 12- month period, while another study involving patients with type 2 diabetes had the average weight loss of 2% over treatment with placebo at one year.

    Using two separate drugs to lose weight can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight loss and the people that go through it one should err along the side of caution and allow the FDA do its job and demand some study be done in order that the public is aware of the side effects and hazards of the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say almost anything to keep people on their medications.

    Researchers discovered that participants investing in this drug for a year, lost excess weight within four weeks and have kept the body weight off throughout the 56 weeks in the study. Contrave can be a combination with the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs that are made up of more than one active ingredient, which can make them more effective and safer.

    Combo-pilling will be the newest fad or also the newest ahead under scrutiny and so it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular will be the fact that since right now there aren't any long term prescription diet pills that have been licensed by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA.

    Seizures really are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug may also raise blood pressure and heartbeat, and shouldn't be used in individuals with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise hypertension and heartrate and must 't be used in patients with uncontrolled high blood pressure levels, along with by you are not heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.

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